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Liver MD™

$ 32.95 $ 31.78


Each Product is a Month's Supply
      • Liver MD™ is one of our most comprehensive formulas because it covers broad-spectrum liver support. It is comprised of all non-GMO ingredients. Specifically, Liver MD™ promotes:

        • Phase I liver detoxification (detoxication)*
        • Phase II liver detoxication*
        • Antioxidant protection*
        • Glutathione production*
        • Healthy Fat metabolism*

        The liver uses an enzyme-based processing and transport system to eliminate toxins and their intermediates. This enzyme-based system primarily involves Phase I & II Conjugation Liver Detoxification (Detoxication). Phase I and II “conjugates” or attaches molecules to the toxins to better control, process and eliminate them. Initially conjugating a toxin can actually temporarily increase its toxicity, therefore antioxidants and toxin neutralizers are integral to this system. For example, Milk Thistle (Silybum marianum) and N-Acetyl Cysteine (NAC) are two superior neutralizers of many liver toxins passing through Phase I & II processing.

        This entire system is essential to the study of metabonomics, a critical science important to devising optimal methodologies to practice proficient regenerative medicine.*

        Liver MD™ contains many other select nutrients and phytonutrients that promote liver regeneration and facilitate the liver in its full range of vital duties.*

        Phase I Conjugation

        Liver Detoxification Support and Healthy Fat Metabolism. Phase I Conjugation Liver Detoxication utilizes a vast system of enzymes collectively termed the cytochrome P450 system. One key job of these enzymes is to snare onto toxins in order to more efficiently pass them on into Phase II Conjugation-Liver Detoxication.* Liver MD™ contains key nutrients to aid Phase I Conjugation-Liver Detoxication.*

        • B-Complex Vitamins provide powerful support for Phase I Conjugation-Liver Detoxication and proper liver fat metabolism. Biotin, Choline, and Inositol are three such B-complex vitamins critical to both Phase I Conjugation and healthy fat metabolism featured in Liver MD™.1,2,3*
        • DIM (diindolylmethane) is a naturally occurring sulfur compound found in cruciferous vegetables, such as cabbage, broccoli or mustard greens. The DIM found in Liver MD™ has been enhanced for optimal absorption, and acts as a powerful promoter to help detoxify xenobiotics and toxic testosterone and estrogen metabolites.4,5,6*

        Phase II Conjugation

        Phase II Conjugation- Liver Detoxication further processes these toxins into less toxic substances in such a manner that enables these toxins to be eliminated. Phase II Conjugation- Liver Detoxication involves six (6) pathways which may be optimized through select nutrients and phytonutrients.* Liver MD™ helps support all six (6) Phase II Conjugation-Liver Detoxication Pathways, namely: Acetylation, Amino Acid Conjugation, Glucuronidation, Glutathione conjugation (Glutathionylation), Methylation, and Sulfation.*

        Phase II Conjugation-Liver Detoxification support:

        • Liver MD™ modulates and supports healthy levels of Acetylation by way of its ingredients: Turmeric (Curcuma longa), Alpha Lipoic Acid (ALA), and DIM.7,8,9,10
        • Liver MD™ modulates and supports healthy levels of Amino Acid Conjugation by way of its ingredients: L-Glycine, NAC and methionine.11,12,13
        • Liver MD™ is composed of ingredients that appear to modulate and support healthy levels of Glucuronidation (the most common phase II reaction and is nearly always a route for detoxifying foreign substances) including Calcium glucarate, NAC, and DIM.14,15,16 The glucuronidation process aids the body in detoxifying and eliminating fungal toxins, steroid hormones and automobile exhaust.*
        • Liver MD™ ingredients promote healthy levels of Glutathione Conjugation. Specifically, ingredients are NAC, Methionine, Glycine, ALA, Curcuma longa and Silybum marianum.17
          • ALA helps facilitate the recharging or renewal of select antioxidants, giving them added life.18
          • Turmeric exerts powerful antioxidant effects that help quench free radicals.
          • Curcuma longa and methionine exert choleretic activity, which promotes the storage and release of bile (i.e., cholagogue effects) from the gallbladder.19,20
          • Silybum marianum reduces liver injury from alcoholism, radiation exposure, toxic mushrooms (Amanita phalloides) and acetaminophen.
          • Plus, emerging evidence suggests Curcuma longa and Silybum marianum also induce regenerative healing effects on the liver.21,22*
        • Liver MD™ ingredients promote healthy levels of Methylation. Specifically, L-Methionine is an amino acid that converts into SAMe, essential to the methylation pathway.23 As a sulfur-containing amino acid, Methionine promotes both fat metabolism and glutathione production.24*
        • Liver MD™ ingredients promote healthy levels of Sulfation. For example, Sulfation is modulated and aided by both methionine as well as NAC.25,26*

        Warning: If pregnant, nursing, or planning on becoming pregnant, do not take this product. 

    • DIM® is a registered trademark of and is licensed from, BioResponse, LLC, Boulder CO US Patent # 6,086,915

Standard Dosage:  As a dietary supplement, take 1 capsule, twice daily, or as directed by your healthcare practitioner. 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • References

    1. Aguilera-Mendez A, Fernandez-Mejia C. The Hypotriglyceridemic Effect of Biotin Supplementation Involves Increased Levels of cGMP and AMPK Activation. Biofactors. 2012 Sep-Oct;38(5):387-94.
    2. Schenkel LC, et al. Choline Supplementation Restores Substrate Balance and Alleviates Complications of Pcyt2 Deficiency. J Nutr Biochem. 2015 Nov;26(11):1221-34.
    3. Zempleni J, Wijeratne SSK, Hassan YI. Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46.
    4. Banerjee S, et al. Attenuation of Multi-targeted Proliferation-linked Signaling by 3,3’-diindolylmethane (DIM): From Bench to Clinic. Metat Res. 2011 Jul-Oct;728(1-2):47-66.
    5. Le HT, et al. Plant-derived 3,3’-Diindolylmethane is a Strong Androgen Antagonist in Human Prostate Cancer Cells. J Biol Chem. 2003 Jun 6;278(23):21136-45.
    6. Smith S, et al. 3,3’-Diindolylymethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells. J Nutri. 2008 Dec;138(12):2379-85.
    7. Yan X, et al. Inhibition of Histone Acetylation by Curcumin Reduces Alcohol-Induced Fetal Cardiac Apoptosis. J Biomed Sci. 2017 Jan 5;24(1):1.
    8. Kalea AZ, Drosatos K, Buxton JL. Nutriepigenetics and Cardiovascular Disease. Curr Opin Clin Nutri Metab Care. 2018 Jul;21(4):252-9.
    9. Valdecantos MP, et al. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Obesity (Silver Spring). 2012 Oct;20(10):1974-83.
    10. Beaver LM, et al. 3m3’-Diindolylmethane, But Not Indole-3-Carbinol, Inhibits Histone Deacetylase Activity in Prostate Cancer Cells. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51.
    11. Van der Sluis R, et al. New Insights into the Catalytic Mechanism of Human Glycine N-Acyltransferase. J Biochem Mol Toxicol. 2017 Nov;31(11).
    12. Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.
    13. Expert Opin Drug Metab Toxicol. 2013 Sep; 9(9):1139-53.
    14. Lin S, et al. Redox-Based Reagents for Chemoselective Methionine Bioconjugation. Science. 2017 Feb 10;355(6325):597-602.
    15. Oredipe OA, Barth RF, Dwivedi C, Webb TE. Dietary Glucarate-Mediated Inhibition of Initiation of Diethylnitrosamine-Induced Hepatocarcinogenesis. Toxicology. 1992 Sep;74(2-3):209-22.
    16. Dean B, et al. Glucuronidation, Oxidative Metabolism, and Bioactivation of Enterolactone in Rhesus Monkeys. Arch Biochem Biophys 2004 Sep 15;429(2):244-51.
    17. Pantuck EJ, et al. Effect of Brussels Sprouts and Cabbage on Drug Conjugation. Clin Pharmacol Ther. 1084 Feb;35(2):161-9.
    18. Bijak M. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaent.)-Chemistry, Bioavailability, and Metabolism. Molecules. 2017 Nov 10;22(11): pii: E1942.
    19. Wnag Y, Wang L, Zhu X, Wang D, Li X. Choleretic Activity of Turmeric and its Active Ingredients. J Food Sci. 2016 Jul;81(7):H1800-6.
    20. Hawkins WB, Hanson PC. Bile Salt Metabolism as Influenced by Pure Amino Acids and Casein Digests. J Exp Med. 1949;90(5):461-73.
    21. Gozeneli O, et al. Effects of Thymoquinone and Curcumin on the Regeneration of Rat Livers Subject to 70% Hepatectomy. Acta Cir Bras. 2018 Feb;33(2):110-6.
    22. Abenavoli L, Capasso R, Milic N, Capasso F. Milk Thistle in Liver Disease: Past, Present, Future. Phytother Res. 2010 Oct;24(10):1423-32.
    23. Pascale RM, Feo CF, Calvisi DF, Feo F. Deregulation of Methionine Metabolism as Determinant of Progression and Prognosis of Hepatocellular Carcinoma. Transl Gastroenterol Hepatol. 2018 Jun 29;3:36.
    24. Ruan T, Li L, Lyu Y, Luo Q, Wu B. Effect of Methionine Deficiency on Oxidative Stress and Apoptosis in the Small Intestines of Broilers. Acta Vet Hung. 2018 Mar;66(1):52-65.
    25. Milkiewicz P, Roma MG, Cardenas R, Mills CO, Elias E, Coleman R. Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. J Hepatol. 2001 Feb;34(2):184-91.
    26. Monti L, et al. N-Acetylcysteine Treatment Ameliorates the Skeletal Phenotype of a Mouse Model of Diastrophic Dysplasia. Hum Mol Genet. 2015 Oct 1;24(19):5570-80.